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Grape Seed (Vitis vinifera)

Grape Seed (Vitis vinifera)

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


Grapes are the fruit of a vine (Vitis vinifera). The whole fruit, skin, leaves and seed of the grape plant are used as medicine. Grape seeds are by-products of the manufacturing of wine. Be careful not to confuse grape with grapefruit, and other similar sounding medicines.

Grape is used for preventing diseases of the heart and blood vessels, varicose veins, hemorrhoids, “hardening of the arteries” (atherosclerosis), high blood pressure, swelling after injury or surgery, heart attack, and stroke.

Some people also use grape as a mild laxative for constipation. You have probably heard of grape “fasts” as part of “detoxification.”

Grape seed is used for diabetes complications such as nerve and eye problems, improving wound healing, preventing tooth decay, preventing cancer, an eye disease called age-related macular degeneration (AMD), poor night vision, liver disorders, and hay fever.

Dried grapes, raisins, or sultanas (white raisins) are used for cough.

Grape leaf is used for attention deficit-hyperactivity disorder (ADHD), chronic fatigue syndrome (CFS), diarrhea, heavy menstrual bleeding, uterine bleeding, and canker sores.

Grape leaf is used as a food, particularly in Greek cooking.

How does it work?

Grape contains flavonoids, which can have antioxidant effects, lower the levels of low density lipoproteins (LDLs, or “bad cholesterol”), relax blood vessels, and reduce the risk of coronary heart disease. The antioxidants in grape might help to prevent heart disease and have other potentially beneficial effects. Red grape varieties provide more antioxidants than white or blush grape varieties.

Grape leaf might reduce inflammation and have astringent effects. In other words, grape leaf seems to be able to draw tissue together, which could help stop bleeding and diarrhea. These properties appear to be greatest in the red leaves.

Traditionally used for

Poor circulation that can cause the legs to swell (chronic venous insufficiency).
Eye stress.
Athletic performance.
Heart disease.
Eye damage caused by diabetes (diabetic retinopathy).
High cholesterol.
High blood pressure.
Dark skin patches on the face (melasma).
Age-related mental decline.
Metabolic syndrome.
Poor night vision.
Nonalcoholic fatty liver disease.
Premenstrual syndrome (PMS).
Treating varicose veins.
Attention deficit-hyperactivity disorder (ADHD).
Chronic fatigue syndrome (CFS).
Heavy menstrual periods.
Age-related macular degeneration (AMD).
Canker sores.
Liver damage.


By Mouth:

For poor blood flow in the legs (chronic venous insufficiency): Standardized red vine grape extract AS 195 (Antistax, Boehringer Ingelheim 360 mg or 720 mg once daily. Grape seed extract as tablets or capsules dosed at 75-300 mg daily for three weeks followed by a maintenance dose of 40-80 mg daily. Grape seed extract proanthocyanidin doses of 150-300 mg per day. Proanthocyanidin is one of the active ingredients in grape.

For reducing eye stress due to glare: Grape seed extract proanthocyanidin doses of 200-300 mg per day.

Possible Side Effects

Grape is SAFE when consumed in amounts commonly found in foods.

Grape is SAFE when taken by mouth in medicinal amounts. Grape seed extracts have been used safely in studies for up to 14 weeks. Eating large quantities of grapes, dried grapes, raisins, or sultanas might cause diarrhea. Some people have allergic reactions to grapes and grape products. Some other potential side effects include stomach upset, indigestion, nausea, vomiting, cough, dry mouth, sore throat, infections, headache, and muscular problems.

Special Precautions & Warnings

Pregnancy and breast-feeding: Not enough is known about the use of grape in medicinal amounts (supplements or amounts that are higher than normal food amounts) during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Bleeding conditions: Grape might slow blood clotting. Taking grape might increase the chances of bruising and bleeding in people with bleeding conditions. However, there are no reports of this occurring in humans.

Surgery: Grape might slow blood clotting. It might cause extra bleeding during and after surgery. Stop using medicinal amounts of grape at least 2 weeks before a scheduled surgery.

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